Rinsho Byori. 2002 Nov;Suppl 123:137-41.

[Telomerase].

[Article in Japanese]

Source

Department of Clinical Laboratory Medicine, Sapporo Medical University, School of Medicine.

Abstract

Telomerase, an intranuclear enzyme, binds to telomeres at chromosome ends, helps to elongate telomere length and is closely linked to attainment of cellular immortality, a step in carcinogenesis. Since telomerase activity has been detected in several human tumors and hematopoietic malignancies, this enzyme is thought to be a useful marker for cancer diagnosis. Among the components of telomerase, human telomerase catalytic subunit(hTERT) is the most important regulatory factor for telomerase activity. Therefore, quantitation of hTERT mRNA expression may be a new approach to measuring telomerase activity.

PMID:: 12652801; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical Online, Meteo Inc - PDF

Medical

Cancer - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Telomerase activity and human telomerase reverse transcriptase mRNA expression are correlated with clinical aggressiveness in soft tissue tumors. [Cancer. 2002]
Telomerase activity and human telomerase reverse transcriptase mRNA expression are correlated with clinical aggressiveness in soft tissue tumors.
Tomoda R, Seto M, Tsumuki H, Iida K, Yamazaki T, Sonoda J, Matsumine A, Uchida A. Cancer. 2002 Sep 1; 95(5):1127-33.
A prospective evaluation of the diagnostic and potential prognostic utility of urinary human telomerase reverse transcriptase mRNA in patients with bladder cancer. [Can J Urol. 2004]
A prospective evaluation of the diagnostic and potential prognostic utility of urinary human telomerase reverse transcriptase mRNA in patients with bladder cancer.
Bowles L, Bialkowska-Hobrzanska H, Bukala B, Nott L, Razvi H. Can J Urol. 2004 Dec; 11(6):2438-44.
Telomerase components as a diagnostic tool in human oral lesions. [Int J Cancer. 1999]
Telomerase components as a diagnostic tool in human oral lesions.
Sumida T, Hamakawa H, Sogawa K, Sugita A, Tanioka H, Ueda N. Int J Cancer. 1999 Jan 5; 80(1):1-4.
Review [Telomerase, cell immortality and cancer]. [Hokkaido Igaku Zasshi. 2001]
Review [Telomerase, cell immortality and cancer].
Watanabe N. Hokkaido Igaku Zasshi. 2001 May; 76(3):127-32.
Review The significance of human telomerase reverse transcriptase (hTERT) in cancer. [Eur J Surg Oncol. 2001]
Review The significance of human telomerase reverse transcriptase (hTERT) in cancer.
Kirkpatrick KL, Mokbel K. Eur J Surg Oncol. 2001 Dec; 27(8):754-60.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

[Telomerase].
[Telomerase].
Rinsho Byori. 2002 Nov ;Suppl 123:137-41.

PubMed
Screening for risk of rehospitalization from home care: use of the outcomes asse...
Screening for risk of rehospitalization from home care: use of the outcomes assessment information set and the probability of readmission instrument.
Res Nurs Health. 2003 Apr ;26(2):118-27.

PubMed
Clinical and radiographic abnormalities in ankylosing spondylitis: a comparison ...
Clinical and radiographic abnormalities in ankylosing spondylitis: a comparison of men and women.
Radiology. 1976 May ;119(2):293-7.

PubMed
Relaxation times of 31P-metabolites in human calf muscle at 3 T.
Relaxation times of 31P-metabolites in human calf muscle at 3 T.
Magn Reson Med. 2003 Apr ;49(4):620-5.

PubMed
Mutations in RAI1 associated with Smith-Magenis syndrome.
Mutations in RAI1 associated with Smith-Magenis syndrome.
Nat Genet. 2003 Apr ;33(4):466-8. Epub 2003 Mar 24 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: