Semin Cell Dev Biol. 2003 Apr;14(2):151-7.

Notch signalling at the crossroads of T cell development and leukemogenesis.

Campese AF, Bellavia D, Gulino A, Screpanti I.

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Department of Experimental Medicine and Pathology, University La Sapienza, Viale Regina Elena 324, 00161 Rome, Italy.

Abstract

Members of the Notch family (e.g. Notch1 and Notch3) have been recently described to play a critical role in T cell development and their constitutive activation has been related to T cell leukaemia in both animal models and human disease. Nevertheless, whether they act as redundant molecules, by affecting the same molecular mechanisms, or play distinct roles in T cell differentiation and/or leukemogenesis is not clear. Altered Notch signalling impairs the developmentally-regulated interplay between pre-TCR signalling, NFkappaB and E2A activities, thus identifying the crucial role of Notch receptors at the cross-roads of disrupted lymphoid differentiation and neoplastic transformation.

PMID:: 12651099; [PubMed - indexed for MEDLINE]

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Review Notch3, another Notch in T cell development. [Semin Immunol. 2003]
Review Notch3, another Notch in T cell development.
Bellavia D, Campese AF, Vacca A, Gulino A, Screpanti I. Semin Immunol. 2003 Apr; 15(2):107-12.
Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis. [Proc Natl Acad Sci U S A. 2002]
Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis.
Bellavia D, Campese AF, Checquolo S, Balestri A, Biondi A, Cazzaniga G, Lendahl U, Fehling HJ, Hayday AC, Frati L, et al. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3788-93. Epub 2002 Mar 12.
Review Notch, a unifying target in T-cell acute lymphoblastic leukemia? [Trends Mol Med. 2003]
Review Notch, a unifying target in T-cell acute lymphoblastic leukemia?
Screpanti I, Bellavia D, Campese AF, Frati L, Gulino A. Trends Mol Med. 2003 Jan; 9(1):30-5.
Review Notch signalling in B cells. [Semin Cell Dev Biol. 2003]
Review Notch signalling in B cells.
He Y, Pear WS. Semin Cell Dev Biol. 2003 Apr; 14(2):135-42.
Review Notch and Ikaros: not only converging players in T cell leukemia. [Cell Cycle. 2007]
Review Notch and Ikaros: not only converging players in T cell leukemia.
Bellavia D, Mecarozzi M, Campese AF, Grazioli P, Gulino A, Screpanti I. Cell Cycle. 2007 Nov 15; 6(22):2730-4. Epub 2007 Aug 15.

See reviews... See all...

Cited by 1 PubMed Central article

HTLV-1 propels thymic human T cell development in "human immune system" Rag2⁻/⁻ gamma c⁻/⁻ mice. [PLoS Pathog. 2011]
HTLV-1 propels thymic human T cell development in "human immune system" Rag2⁻/⁻ gamma c⁻/⁻ mice.
Villaudy J, Wencker M, Gadot N, Gillet NA, Scoazec JY, Gazzolo L, Manz MG, Bangham CR, Dodon MD. PLoS Pathog. 2011 Sep; 7(9):e1002231. Epub 2011 Sep 1.

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