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Semin Cell Dev Biol. 2003 Apr;14(2):135-42.

Notch signalling in B cells.

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  • 1Department of Pathology, Institute for Medicine and Engineering, Abramson Family Cancer Research Institute, University of Pennsylvania, 611 BRB II/III, 421 Curie Boulevard, Philadelphia, PA 19104-3111, USA.


Notch signalling is likely to regulate multiple aspects of lymphoid development and function. During T cell development, Notch signalling is required for commitment of the earliest progenitor, and may also function during other developmental stages. T cell commitment from a common lymphoid progenitor occurs at the expense of B cell development, suggesting that Notch signalling inhibits the earliest stage of B lymphopoiesis. In contrast, recent evidence suggests that Notch promotes the development of marginal zone lymphocytes. Not only is Notch required for later stages of B cell development, but several viral proteins appear to utilize Notch signalling in B cells to mediate their functions. In this review, we will focus on potential roles of Notch signalling in B lymphopoiesis and also consider how viral proteins may utilize Notch signalling in B cells.

Copyright 2003 Elsevier Science Ltd.

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