Rube Goldberg goes (ribo)nuclear? Molecular switch...[RNA. 2003]

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1: RNA. 2003 Apr;9(4):377-83. Links

Rube Goldberg goes (ribo)nuclear? Molecular switches and sensors made from RNA.

Silverman SK.

Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA. scott@scs.uiuc.edu

Switches and sensors play important roles in our everyday lives. The chemical properties of RNA make it amenable for use as a switch or sensor, both artificially and in nature. This review focuses on recent advances in artificial RNA switches and sensors. Researchers have been applying classical biochemical principles such as allostery in elegant ways that are influencing the development of biosensors and other applications. Particular attention is given here to allosteric ribozymes (aptazymes) that are regulated by small organic molecules, by proteins, or by oligonucleotides. Also discussed are ribozymes whose activities are controlled by various nonallosteric strategies.

PMID: 12649489 [PubMed - indexed for MEDLINE]

PMCID: PMC1370404

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[Trends Biotechnol. 1999]
ReviewSensors made of RNA: tailored ribozymes for detection of small organic molecules, metals, nucleic acids and proteins.
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[IEE Proc Nanobiotechnol. 2006]
ReviewAllosteric aptamers and aptazymes as probes for screening approaches.
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[Curr Opin Mol Ther. 2005]
ReviewEngineered allosteric ribozymes as biosensor components.
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[Curr Opin Biotechnol. 2002]
A novel strategy for selection of allosteric ribozymes yields RiboReporter sensors for caffeine and aspartame.
Nucleic Acids Res. 2004; 32(5):1756-66. Epub 2004 Mar 16.

[Nucleic Acids Res. 2004]
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[BMC Bioinformatics. 2006]
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