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    Curr Opin Cell Biol. 2003 Apr;15(2):241-6.

    Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease.

    Lin SJ, Guarente L.

    Source

    Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, MA 02139, USA

    Abstract

    Nicotinamide adenine dinucleotide (NAD) is a ubiquitous biological molecule that participates in many metabolic reactions. Recent studies show that NAD also plays important roles in transcriptional regulation, longevity, calorie-restriction-mediated life-span extension and age-associated diseases. It has been shown that NAD affects longevity and transcriptional silencing through the regulation of the Sir2p family, which are NAD-dependent deacetylases. Many human diseases are associated with changes in NAD level and/or the NAD : NADH ratio, raising the possibility that the Sir2p family might play a role in these diseases.

    PMID:
    12648681
    [PubMed - indexed for MEDLINE]

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