Pediatrics. 1976 Apr;57(4):518-20.

Theophylline secretion into breast milk.

Abstract

The infant of an asthmatic patient showed irritability associated with ingestion of breast milk only on days when the mother was taking theophylline. Pharmacokinetic studies in this woman and in four other subjects revealed that theophylline distributes well into breast milk. The average milk to serum concentration ratio of the drug was about 0.7 and milk concentrations paralleled the time-course of serum and saliva concentrations. On a relative body weight basis, a nursing infant would usually receive less than 10% of the mother's dose of theophylline which is normally an inconsequential amount.

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[Pharmacokinetics of drugs from the breast-feeding mother passing into the body of the infant, using theophylline as an example]. [Monatsschr Kinderheilkd. 1983]
[Pharmacokinetics of drugs from the breast-feeding mother passing into the body of the infant, using theophylline as an example].
Reinhardt D, Richter O, Brandenburg G. Monatsschr Kinderheilkd. 1983 Feb; 131(2):66-70.
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Review Drugs in human milk. Clinical pharmacokinetic considerations. [Clin Pharmacokinet. 1988]
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Cited by 6 PubMed Central articles

Terbutaline in breast milk. [Br J Clin Pharmacol. 1982]
Terbutaline in breast milk.
Boréus LO, de Château PU. Br J Clin Pharmacol. 1982 May; 13(5):731-2.
Clindamycin passage into human milk. [Br J Clin Pharmacol. 1982]
Clindamycin passage into human milk.
Stéen B, Rane A. Br J Clin Pharmacol. 1982 May; 13(5):661-4.
Do saliva concentrations predict plasma unbound theophylline concentrations? A problem re-examined. [Br J Clin Pharmacol. 1984]
Do saliva concentrations predict plasma unbound theophylline concentrations? A problem re-examined.
Knott C, Bateman M, Reynolds F. Br J Clin Pharmacol. 1984 Jan; 17(1):9-14.

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