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Brain Res. 2003 Apr 4;968(1):167-70.

Antisense knockdown of neuronal nitric oxide synthase antagonizes nitrous oxide-induced behavior.

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  • 1Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, 99164-6534, Pullman, WA, USA.

Abstract

The behavioral effects of nitrous oxide (N(2)O) were antagonized by non-specific inhibitors of nitric oxide synthase (NOS). To identify the isoform of NOS involved in this response, mice were pretreated with an antisense oligodeoxynucleotide (AS-ODN) against neuronal NOS, and then tested in a light/dark exploration paradigm. The AS-ODN but not the mismatch ODN significantly antagonized N(2)O induced behavior and also reduced NOS activity in the cerebellum and hippocampus. These results implicate neuronal NOS in the N(2)O response.

PMID:
12644275
[PubMed - indexed for MEDLINE]
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