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Brain Res. 2003 Apr 4;968(1):167-70.

Antisense knockdown of neuronal nitric oxide synthase antagonizes nitrous oxide-induced behavior.

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  • 1Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, 99164-6534, Pullman, WA, USA.


The behavioral effects of nitrous oxide (N(2)O) were antagonized by non-specific inhibitors of nitric oxide synthase (NOS). To identify the isoform of NOS involved in this response, mice were pretreated with an antisense oligodeoxynucleotide (AS-ODN) against neuronal NOS, and then tested in a light/dark exploration paradigm. The AS-ODN but not the mismatch ODN significantly antagonized N(2)O induced behavior and also reduced NOS activity in the cerebellum and hippocampus. These results implicate neuronal NOS in the N(2)O response.

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