Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Trends Parasitol. 2003 Mar;19(3):135-43.

The Plasmodium sporozoite journey: a rite of passage.

Author information

  • 1Michael Heidelberger Division, Department of Pathology, New York University School of Medicine, New York, NY 10016, USA. kappes01@popmail.uky.edu

Abstract

Sporozoites are the most versatile of the invasive stages of the Plasmodium life cycle. During their passage within the mosquito vector and the vertebrate host, sporozoites display diverse behaviors, including gliding locomotion and invasion of, migration through and egress from target cells. At the end of the journey, sporozoites invade hepatocytes and transform into exoerythrocytic stages, marking the transition from the pre-erythrocytic to the erythrocytic part of the life cycle. This article discusses recent work, mostly done with rodent malaria parasites, that has contributed to a better understanding of the sporozoites' complex biology and which has opened up new avenues for future sporozoite research.

PMID:
12643997
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk