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Alcohol Alcohol. 2003 Mar-Apr;38(2):189-93.

Impaired serum cortisol stress response is a predictor of early relapse.

Author information

  • 1Department of Psychiatry and Psychotherapy, University of Luebeck, Germany.

Abstract

AIMS:

to investigate a possible association of cortisol stress response during early abstention with relapse.

METHODS:

Thirty-six alcohol-dependent males, half of them with a comorbid anxiety disorder, and 15 healthy controls were exposed to a standardized psychosocial stress test. Thirty-one of the patients were assessed for relapse 6 weeks after discharge.

RESULTS:

The relapsers showed almost no cortisol responses in the stress test. Comorbid anxiety disorder influenced neither stress response nor relapse.

CONCLUSIONS:

During early abstention from alcohol, reduced stress-responsivity of the hypothalamo-pituitary-adrenocortical axis seems to be connected to early relapse.

PMID:
12634269
[PubMed - indexed for MEDLINE]
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