Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3351-6. Epub 2003 Mar 11.

Generalized singular value decomposition for comparative analysis of genome-scale expression data sets of two different organisms.

Author information

  • 1Department of Genetics, Stanford University, Stanford, CA 94305. orly@genome.stanford.edu

Abstract

We describe a comparative mathematical framework for two genome-scale expression data sets. This framework formulates expression as superposition of the effects of regulatory programs, biological processes, and experimental artifacts common to both data sets, as well as those that are exclusive to one data set or the other, by using generalized singular value decomposition. This framework enables comparative reconstruction and classification of the genes and arrays of both data sets. We illustrate this framework with a comparison of yeast and human cell-cycle expression data sets.

PMID:
12631705
[PubMed - indexed for MEDLINE]
PMCID:
PMC152296
Free PMC Article

Images from this publication.See all images (4)Free text

Fig 1.
Fig 2.
Fig 3.
Fig 4.
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk