Trends Pharmacol Sci. 2003 Mar;24(3):107-9.

Salvinorin A: the "magic mint" hallucinogen finds a molecular target in the kappa opioid receptor.

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Department of Biochemistry, Case Western Reserve University Medical School, 10900 Euclid Avenue, Cleveland, OH 44106, USA.

Abstract

Salvinorin A, a neoclerodane diterpene, is the most potent naturally occurring hallucinogen known and rivals the synthetic hallucinogen lysergic acid diethylamide in potency. Recently, the molecular target of salvinorin A was identified as the kappa opioid receptor (KOR). Salvinorin A represents the only known non-nitrogenous KOR selective agonist. Based on the selectivity of salvinorin A for the KOR, this receptor represents a potential molecular target for the development of drugs to treat disorders characterized by alterations in perception, including schizophrenia, Alzheimer's disease and bipolar disorder.

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Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist. [Proc Natl Acad Sci U S A. 2002]
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Roth BL, Baner K, Westkaemper R, Siebert D, Rice KC, Steinberg S, Ernsberger P, Rothman RB. Proc Natl Acad Sci U S A. 2002 Sep 3; 99(18):11934-9. Epub 2002 Aug 21.
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Cited by 13 PubMed Central articles

Human psychopharmacology and dose-effects of salvinorin A, a kappa opioid agonist hallucinogen present in the plant Salvia divinorum. [Drug Alcohol Depend. 2011]
Human psychopharmacology and dose-effects of salvinorin A, a kappa opioid agonist hallucinogen present in the plant Salvia divinorum.
Johnson MW, MacLean KA, Reissig CJ, Prisinzano TE, Griffiths RR. Drug Alcohol Depend. 2011 May 1; 115(1-2):150-5. Epub 2010 Dec 4.
Novel neoclerodane diterpene derivatives from the smoke of salvinorin A. [Tetrahedron Lett. 2010]
Novel neoclerodane diterpene derivatives from the smoke of salvinorin A.
Ma Z, Deng G, Lee DY. Tetrahedron Lett. 2010 Sep 29; 51(39):5207-5209.
Structure-based design, synthesis, and biochemical and pharmacological characterization of novel salvinorin A analogues as active state probes of the kappa-opioid receptor. [Biochemistry. 2009]
Structure-based design, synthesis, and biochemical and pharmacological characterization of novel salvinorin A analogues as active state probes of the kappa-opioid receptor.
Yan F, Bikbulatov RV, Mocanu V, Dicheva N, Parker CE, Wetsel WC, Mosier PD, Westkaemper RB, Allen JA, Zjawiony JK, et al. Biochemistry. 2009 Jul 28; 48(29):6898-908.

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