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Annu Rev Nutr. 2003;23:303-13. Epub 2003 Feb 26.

GUGULIPID: a natural cholesterol-lowering agent.

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  • 1Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA. nurizar@bcm.tmc.edu

Abstract

The resin of the Commiphora mukul tree has been used in Ayurvedic medicine for more than 2000 years to treat a variety of ailments. Studies in both animal models and humans have shown that this resin, termed gum guggul, can decrease elevated lipid levels. The stereoisomers E- and Z-guggulsterone have been identified as the active agents in this resin. Recent studies have shown that these compounds are antagonist ligands for the bile acid receptor farnesoid X receptor (FXR), which is an important regulator of cholesterol homeostasis. It is likely that this effect accounts for the hypolipidemic activity of these phytosteroids.

PMID:
12626688
[PubMed - indexed for MEDLINE]
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