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1: Appl Environ Microbiol. 2003 Mar;69(3):1670-9.Click here to read Click here to read Links

Synthesis of imidazol-2-yl amino acids by using cells from alkane-oxidizing bacteria.

Mikolasch A, Hammer E, Schauer F.

Institut für Mikrobiologie, Ernst-Moritz-Arndt-Universität, F.-L.-Jahn-Strasse 15, 17487 Greifswald, Germany. annett.mikolasch@gmx.de

Sixty-one strains of alkane-oxidizing bacteria were tested for their ability to oxidize N-(2-hexylamino-4-phenylimidazol-1-yl)-acetamide to imidazol-2-yl amino acids applicable for pharmaceutical purposes. After growth with n-alkane, 15 strains formed different imidazol-2-yl amino acids identified by chemical structure analysis (mass and nuclear magnetic resonance spectrometry). High yields of imidazol-2-yl amino acids were produced by the strains Gordonia rubropertincta SBUG 105, Gordonia terrae SBUG 253, Nocardia asteroides SBUG 175, Rhodococcus erythropolis SBUG 251, and Rhodococcus erythropolis SBUG 254. Biotransformation occurred via oxidation of the alkyl side chain and produced 1-acetylamino-4-phenylimidazol-2-yl-6-aminohexanoic acid and the butanoic acid derivative. In addition, the acetylamino group of these products and of the substrate was transformed to an amino group. The product pattern as well as the transformation pathway of N-(2-hexylamino-4-phenylimidazol-1-yl)-acetamide differed in the various strains used.

PMID: 12620858 [PubMed - indexed for MEDLINE]

PMCID: PMC150088

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