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Fertil Steril. 2003 Mar;79(3):621-3.

First live birth after ovarian stimulation using a chimeric long-acting human recombinant follicle-stimulating hormone (FSH) agonist (recFSH-CTP) for in vitro fertilization.

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  • 1Center for Reproductive Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.

Abstract

OBJECTIVE:

To report the first pregnancy and live birth after ovarian stimulation using a chimeric long-acting human recombinant FSH agonist (recFSH-CTP) for IVF.

DESIGN:

Case report.

SETTING:

Tertiary fertility center.

PATIENT(S):

A 32-year-old woman with a 7-year history of primary infertility.

INTERVENTION(S):

Ovarian stimulation with a single SC injection of 180 microg recFSH-CTP on cycle day 3, followed by daily injections of 150 IU recFSH from cycle day 10 onward, combined with daily GnRH antagonist 0.25 mg SC to prevent a premature LH rise. Final oocyte maturation was induced by 10,000 IU hCG.

MAIN OUTCOME MEASURE(S):

First ongoing pregnancy obtained with recFSH-CTP.

RESULT(S):

Twelve oocytes were retrieved. Ten oocytes were fertilized in vitro by intracytoplasmic sperm injection, and from these 10 oocytes, two embryos were subsequently transferred after 3 days of culture. A pregnancy test 2 weeks after ET was positive, and ultrasound investigation revealed an intact, intrauterine, singleton pregnancy after 12 weeks.

CONCLUSION(S):

The first pregnancy and live birth was achieved after ovarian stimulation using recFSH-CTP for IVF.

PMID:
12620451
[PubMed - indexed for MEDLINE]
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