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Fertil Steril. 2003 Mar;79(3):512-6.

A retrospective case-control study of developmental and other outcomes in a cohort of Australian children conceived by intracytoplasmic sperm injection compared with a similar group in the United Kingdom.

Author information

  • 1Department of Child Health Royal Free and University College Medical School, London, United Kingdom. icsi@rfc.ucl.ac.uk

Abstract

OBJECTIVE:

To investigate the possibility that children born after ICSI were at increased risk for neurodevelopmental delay.

DESIGN:

Retrospective case-control study.

SETTING:

IVF clinic.

PATIENT(S):

Fifty-eight singleton children born after ICSI and 38 normally conceived singleton children (controls), matched for relevant sociodemographic characteristics, from Australia and 208 case-patients and 221 controls from the United Kingdom.

MAIN OUTCOME MEASURE(S):

Antenatal and perinatal, and sociodemographic characteristics; physical health, including congenital abnormalities; and neurodevelopment by using the Griffiths scales of mental development.

RESULT(S):

Eighty-five percent of case-patients and 96% controls were assessed at a mean age of 13 months. Neurodevelopmental scores were similar in all children. Perinatal outcome was similar, apart from more caesarean sections in the case-patients. Rates of congenital anomalies were similar (5.6% among case-patients vs. 5.7% among controls). Children from fathers with oligozoospermia showed no extra problems. Children born after ICSI in the United Kingdom and Australia were similar.

CONCLUSION(S):

Children conceived after ICSI did not differ from their naturally conceived peers in physical health or development at ages up to 15 months.

PMID:
12620432
[PubMed - indexed for MEDLINE]
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