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Curr Biol. 2003 Mar 4;13(5):R195-7.

Transcriptional activation: getting a grip on condensed chromatin.

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  • 1Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Biotech 2, Suite 210, Worcester, MA 01605, USA.


Chromosomal transcription involves the concerted action of enormous, multisubunit chromatin remodeling complexes. A recent study, however, suggests a different and surprising viewpoint in which these protein assemblies are quite dynamic and individual subunits play key roles in chromatin remodeling.

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