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Genome Biol. 2003;4(2):204. Epub 2003 Jan 30.

DNA replication: telling time with microarrays.

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  • 1Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.

Abstract

A long-standing hypothesis about eukaryotic DNA replication is that the late-replicating regions are transcriptionally inert and that repressing transcription delays replication initiation. But do contrasting results from yeast and a recent study in Drosophila imply that replication timing and transcriptional activity are differentially regulated in yeast and higher eukaryotes?

PMID:
12620111
[PubMed - indexed for MEDLINE]
PMCID:
PMC151294
Free PMC Article
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