Overview of the voltage-gated sodium channel famil...[Genome Biol. 2003]

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1: Genome Biol. 2003;4(3):207. Epub 2003 Feb 24. Links

Overview of the voltage-gated sodium channel family.

Yu FH, Catterall WA.

Department of Pharmacology, University of Washington, Seattle, WA 98195-7280, USA.

Selective permeation of sodium ions through voltage-dependent sodium channels is fundamental to the generation of action potentials in excitable cells such as neurons. These channels are large integral membrane proteins and are encoded by at least ten genes in mammals. The different sodium channels have remarkably similar functional properties, but small changes in sodium-channel function are biologically relevant, as underscored by mutations that cause several human diseases of hyperexcitability.

PMID: 12620097 [PubMed - indexed for MEDLINE]

PMCID: PMC153452

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ReviewInternational Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.
Pharmacol Rev. 2005 Dec; 57(4):397-409.

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ReviewVoltage-gated sodium channels: action players with many faces.
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Cited by 15 PubMed Central articles

Thermal and chemical unfolding and refolding of a eukaryotic sodium channel.
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Alpha-scorpion toxin impairs a conformational change that leads to fast inactivation of muscle sodium channels.
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