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Genome Biol. 2003;4(3):207. Epub 2003 Feb 24.

Overview of the voltage-gated sodium channel family.

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  • 1Department of Pharmacology, University of Washington, Seattle, WA 98195-7280, USA.

Abstract

Selective permeation of sodium ions through voltage-dependent sodium channels is fundamental to the generation of action potentials in excitable cells such as neurons. These channels are large integral membrane proteins and are encoded by at least ten genes in mammals. The different sodium channels have remarkably similar functional properties, but small changes in sodium-channel function are biologically relevant, as underscored by mutations that cause several human diseases of hyperexcitability.

PMID:
12620097
PMCID:
PMC153452
[PubMed - indexed for MEDLINE]
Free PMC Article
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