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Age Ageing. 2003 Mar;32(2):200-4.

Long-term cognitive and functional decline in late onset Alzheimer's disease: therapeutic implications.

Author information

  • 1University of Southampton, Clinical Neurosciences Research Division, Memory Assessment and Research Centre, Moorgreen Hospital, Botley Road, Southampton SO30 3JB, UK. ch4@soton.ac.uk

Abstract

BACKGROUND:

National Institute of Clinical Excellence guidelines advocate the use of the Mini-Mental Test Examination and a functional assessment as a means of measuring treatment response. However, there is little knowledge of the change expected in those with Alzheimer's disease in clinical practice.

OBJECTIVE:

to describe the long-term variability of the Mini-Mental Test Examination and Blessed Dementia Rating Scale.

METHOD:

374 Alzheimer's disease patients referred to psychiatric services in southeast London were followed annually over a 3-year period.

RESULTS:

the mean Mini-Mental Test Examination score for the total group at baseline was 9.9 points. Individual variability in the rate of cognitive and functional decline is large and around 40% of patients after 1 year, and up to one-quarter of patients after 3 years who survived, show no change or an improvement in scores compared with baseline measures.

CONCLUSIONS:

in the evaluation of individual treatment response the rate of change, as measured by the Mini-Mental Test Examination and Blessed Dementia Rating Scale, is of limited value.

PMID:
12615565
[PubMed - indexed for MEDLINE]
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