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Curr Opin Microbiol. 2003 Feb;6(1):7-14.

The various and varying roles of specific chaperones in type III secretion systems.

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  • 1Unité de Pathogénie Microbienne Moléculaire, INSERM U389, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France. cparsot@pasteur.fr


The type III secretion pathway is used by numerous Gram-negative pathogenic bacteria to deliver proteins within the membrane or the cytoplasm of eukaryotic cells with which these bacteria interact. Secretion is regulated by external signals. This requires that, before being secreted, proteins are stored in the cytoplasm where they need to be stabilised, separated from other interaction partners, and maintained in a secretion-competent state. Specialised, energy-independent chaperones play various roles in these functions by associating in the cytoplasm with proteins before their secretion. Some chaperones are also directly involved in modulating transcription in response to secretion.

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