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Pediatr Infect Dis J. 2003 Feb;22(2):199-200.

Capofungin therapy for Aspergillus lung infection in a boy with chronic granulomatous disease.

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  • 1Department of Pediatrics, University of Dresden, Germany.


Neutrophils of patients with chronic granulomatous disease (CGD) are profoundly defective in killing microorganisms. As in patients with chemotherapy-induced neutropenia, CGD patients are highly susceptible to life-threatening invasive Aspergillus infections, and conventional antimycotic treatment is not always successful. The new drug, caspofungin, was used to treat Aspergillus lung infection in one child with CGD.

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