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Bioinformatics. 2003 Mar 1;19(4):524-31.

The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models.

Author information

  • 1Control and Dynamical Systems, MC 107-81, California Institute of Technology, Pasadena, CA 91125, USA. sysbio-team@caltech.edu



Molecular biotechnology now makes it possible to build elaborate systems models, but the systems biology community needs information standards if models are to be shared, evaluated and developed cooperatively.


We summarize the Systems Biology Markup Language (SBML) Level 1, a free, open, XML-based format for representing biochemical reaction networks. SBML is a software-independent language for describing models common to research in many areas of computational biology, including cell signaling pathways, metabolic pathways, gene regulation, and others.


The specification of SBML Level 1 is freely available from http://www.sbml.org/

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