Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Drug Alcohol Depend. 2003 Mar 1;69(2):175-81.

Intravenous use of prescribed sublingual buprenorphine tablets by drug users receiving maintenance therapy in France.

Author information

  • 1Département de Santé Publique and service de Santé publique, AP-HP, CHU Cochin-Port Royal, Université René Descartes, Paris, France. genaelle.vidal-trecan@cochin.univ-paris5.fr

Abstract

BACKGROUND:

In 1996, sublingual buprenorphine was authorized for prescription in France for maintenance therapy (MT). MT should facilitate the rehabilitation of opioid-dependent drug users and reduce the risks associated with injection. However, misuse and side effects have been reported.

OBJECTIVES:

To assess the frequency of buprenorphine injection in 404 subjects on buprenorphine MT and to determine the factors associated with the injection of buprenorphine.

METHODS:

A cross-sectional survey was used to collect data from subjects on buprenorphine MT seeking treatment from health care networks, specialized structures, a prison and a hostel in three different regions of France (1998-1999). Information was collected by trained interviewers using a structured questionnaire.

RESULTS:

About half (46.5%) of the subjects on MT (188/404) had ever injected buprenorphine; 67.2% of this subgroup had since used both injected and sublingual buprenorphine. Variables associated with buprenorphine injection were having injected a substance other than buprenorphine (odds ratio (OR): 13.18; 95% CI: 5.36-32.42), cannabis use (OR: 2.34; 95% CI: 1.51-3.63) and having a source of income other than a salary (OR: 1.58; 95% CI: 1.02-2.45) and heroin use (OR: 0.23; 95% CI: 0.09-0.61).

CONCLUSIONS:

To decrease buprenorphine injection, prescribers of buprenorphine should participate in networks with specialized centers, and social and professional rehabilitation programs should be implemented for subjects on buprenorphine MT.

Copyright 2002 Elsevier Science Ireland Ltd.

PMID:
12609698
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk