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Transplantation. 2003 Feb 27;75(4):562-3.

Simultaneous pancreas-kidney transplantation in patients with antiphospholipid syndrome.

Author information

  • 1Department of Surgery, Knappschaftskrankenhaus Ruhr-University Bochum, Bochum, Germany. christoph.wullstein@kgu.de

Abstract

BACKGROUND:

Graft thrombosis is one of the main reasons of graft loss following simultaneous pancreas-kidney transplantation (SPK). Although antiphospholipid syndrome (APLS) is known as a high risk for graft thrombosis in kidney transplants alone, little is known about APLS in SPK.

METHODS:

Between September 2000 and December 2001, 45 SPK were performed. The treatment and clinical course of 2 patients with APLS is presented.

RESULTS:

In one patient, APLS was known before transplantation. After SPK, she was treated by systemic heparin followed by coumarin. Both grafts are doing well 5 months posttransplant. The second patient underwent SPK without knowledge of APLS. The patient developed a deep vein thrombosis 5 weeks posttransplant. Hypercoagulability screening revealed APLS. Treatment consisted of systemic anticoagulation. Grafts were not affected.

CONCLUSION:

SPK can successfully be performed in APLS patients if anticoagulation is performed consistently. To reduce the risk of graft thrombosis, a pretransplant screening for APLS would probably be of benefit.

PMID:
12605129
[PubMed - indexed for MEDLINE]
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