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    J Gen Virol. 2003 Mar;84(Pt 3):567-72.

    Role of type I and type II interferon responses in recovery from infection with an encephalitic flavivirus.

    Source

    Division of Immunology and Cell Biology, John Curtin School of Medical Research, The Australian National University, PO Box 334, Canberra, ACT 2601, Australia. Mario.Lobigs@anu.edu.au

    Abstract

    We have investigated the contribution of the interferon (IFN)-alpha/beta system, IFN-gamma and nitric oxide to recovery from infection with Murray Valley encephalitis virus, using a mouse model for flaviviral encephalitis where a small dose of virus was administered to 6-week-old wild-type and gene knockout animals by the intravenous route. We show that a defect in the IFN-alpha/beta responses results in uncontrolled extraneural virus growth, rapid virus entry into the brain and 100 % mortality. In contrast, mice deficient in IFN-gamma or nitric oxide production display an only marginally increased susceptibility to infection with the neurotropic virus.

    PMID:
    12604807
    [PubMed - indexed for MEDLINE]
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