Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Nature. 2003 Feb 20;421(6925):848-52.

Yeast genome duplication was followed by asynchronous differentiation of duplicated genes.

Author information

  • 1BioCentrum-DTU, Technical University of Denmark, Building 301, DK-2800 Lyngby, Denmark.


Gene redundancy has been observed in yeast, plant and human genomes, and is thought to be a consequence of whole-genome duplications. Baker's yeast, Saccharomyces cerevisiae, contains several hundred duplicated genes. Duplication(s) could have occurred before or after a given speciation. To understand the evolution of the yeast genome, we analysed orthologues of some of these genes in several related yeast species. On the basis of the inferred phylogeny of each set of genes, we were able to deduce whether the gene duplicated and/or specialized before or after the divergence of two yeast lineages. Here we show that the gene duplications might have occurred as a single event, and that it probably took place before the Saccharomyces and Kluyveromyces lineages diverged from each other. Further evolution of each duplicated gene pair-such as specialization or differentiation of the two copies, or deletion of a single copy--has taken place independently throughout the evolution of these species.

[PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Secondary Source ID

Publication Types

MeSH Terms

Secondary Source ID

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Icon for Nature Publishing Group Icon for Faculty of 1000
    Loading ...
    Write to the Help Desk