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Curr Opin Neurobiol. 2003 Feb;13(1):111-8.

Assembly and plasticity of the glutamatergic postsynaptic specialization.

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  • 1University of California at San Francisco School of Medicine, 513 Parnassus Avenue, San Francisco, California 94143-0444, USA.


Glutamate mediates most excitatory synaptic transmission in the brain. Synaptic strength at glutamatergic synapses shows a remarkable degree of use-dependent plasticity and such modifications may represent a physiological correlate to learning and memory. Glutamate receptors and downstream enzymes are organized at synapses by cytoskeletal proteins containing multiple protein-interacting domains. Recent studies demonstrate that these 'scaffolding' proteins within the postsynaptic specialization have the capacity to promote synaptic maturation, influence synapse size, and modulate glutamate receptor function.

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