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Curr Opin Neurobiol. 2003 Feb;13(1):26-33.

Cell cycle and cell fate interactions in neural development.

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  • 1Scuola Normale Superiore/Dipartimento di Fisiologia e Biochimica, Sezione di Biologia Cellulare e dello Sviluppo, Universit√† di Pisa, Via Carducci 13, Ghezzano, 56010, Pisa, Italy.


Mechanisms coupling cell cycle and cell fate operate at different steps during neural development. Intrinsic factors control the cell proliferation of distinct brain regions and changes of cell fate competence, whereas components of the cell cycle machinery could play a major role in setting the appropriate timing of the generation of different cell types.

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