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Zhonghua Nan Ke Xue. 2002 Dec;8(6):414-5.

[The apoptosis in damaged testicular tissue caused by varicocele].

[Article in Chinese]

Author information

  • 1Department of Urology, Renmin Hospital, Wuhan University, Wuhan, Hubei 430060, China.

Abstract

OBJECTIVES:

To investigate the effects of experimental varicocele on apoptosis of spermatogenic cells in rats.

METHODS:

Experimental varicocele was induced by partial ligation of the left renal vein in Wistar rat. Apoptosis cells were detected by in situ terminal deoxynucleotityl transferase-mediated dTUP nick end labeling(TUNEL) technique.

RESULTS:

There was certain proportion of apoptosis cells in spermatogenic cells in control group rats. The incidence of apoptosis increased remarkably in experimental group, the testicular growth was slower than that in control group.

CONCLUSIONS:

The apoptosis of spermatogenic cells caused by varicocele may play an important role in leading to subfertility.

PMID:
12593014
[PubMed - indexed for MEDLINE]
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