Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Trends Neurosci. 2003 Mar;26(3):147-54.

Role of dendritic synapse location in the control of action potential output.

Author information

  • 1Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia. srw@mrc-lamb.cam.ac.uk

Abstract

How effective are synaptic inputs made at different dendritic sites in the control of action potential output? Recent technical advances have allowed direct observation of the amplitude and time course of excitatory synaptic inputs generated at defined dendritic sites. These findings indicate that contrasting mechanisms exist to enhance the impact of dendritic excitatory inputs to pyramidal neurons of the neocortex and hippocampus. Furthermore, multiple sites of synaptic integration have been revealed, suggesting that proximal and distal inputs are likely to be integrated in different ways. Taken together, these data emphasize the cell- and input-specific strategies used by neurons to enhance the impact of dendritic inputs on action potential generation.

PMID:
12591217
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk