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1: Intern Med. 2003 Jan;42(1):48-52. Links

Drug-induced hepatitis with autoimmune features during minocycline therapy.

Abe M, Furukawa S, Takayama S, Michitaka K, Minami H, Yamamoto K, Horiike N, Onji M.

Third Department of Internal Medicine, Ehime University School of Medicine, Shigenobu-cho, Ehime 791-0295.

A 25-year-old woman with no history of liver disease developed liver dysfunction associated with severe jaundice and general malaise following a prolonged therapy with minocycline for acne vulgaris. Serum anti-nuclear antibody was detected and immunoglobulin G level was elevated. Symptoms resolved and liver function normalized following minocycline discontinuation and corticosteroid administration. Our diagnosis was drug-induced hepatitis with autoimmune features, as liver histology revealed acute hepatitis. Drug-induced hepatitis should be considered when liver dysfunction or systemic symptoms develops during long-term minocycline therapy.

PMID: 12583618 [PubMed - indexed for MEDLINE]