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The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3.
Li Y, Inoki K, Vacratsis P, Guan KL.
J Biol Chem. 2003 Apr 18;278(16):13663-71. Epub 2003 Feb 11.
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14-3-3beta binds to and negatively regulates the tuberous sclerosis complex 2 (TSC2) tumor suppressor gene product, tuberin.
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J Biol Chem. 2003 Jan 24;278(4):2089-92. Epub 2002 Dec 4.
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