Display Settings:

Format

Send to:

Choose Destination
Biochim Biophys Acta. 2003 Feb 17;1593(2-3):115-20.

Zyxin and paxillin proteins: focal adhesion plaque LIM domain proteins go nuclear.

Author information

  • 1Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215-2406, USA.

Abstract

Zyxin and paxillin are the prototypes of two related subfamilies of LIM domain proteins that are localized primarily at focal adhesion plaques. However, recent work has shown that zyxin/paxillin family proteins also shuttle through the nucleus. These proteins may enter the nucleus by association with other proteins, but are exported from the nucleus by means of intrinsic leucine-rich nuclear export sequences. Zyxin/paxillin proteins may regulate gene transcription by interaction with transcription factors. In some cases, misregulation of nuclear functions of zyxin/paxillin proteins appear to be associated with pathogenic effects.

PMID:
12581855
[PubMed - indexed for MEDLINE]
Free full text

LinkOut - more resources

Full Text Sources

Other Literature Sources

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk