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J Chromatogr A. 2003 Jan 24;985(1-2):29-38.

Comprehensive two-dimensional gas chromatography: metrics, potentials, limits.

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  • 1Fast GC Consulting, P.O. Box 585, Hockessin, DE 19707, USA.


Metrics for evaluation of separation performance of comprehensive two-dimensional gas chromatography (GCxGC) and for quantitative comparison of that performance with similar performance of its 1D (one-dimensional) counterparts are described. The performance improvement can be expressed via reduction in the saturation of a chromatogram or-in the case of the uniform distribution of peaks along the second dimension--via the peak capacity gain due to GCxGC. An order of magnitude peak capacity gain due to the comprehensive GCxGC is possible under optimal conditions. Optimal parameters of the second dimension column as well as the optimal operational conditions for that column and for the modulator in a comprehensive GCxGC are also presented.

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