Science. 1976 Apr 23;192(4237):372-4.

Growth promotion by homocysteic acid.

Abstract

Homocysteic acid, H03SCH2CH2CHNH2CO2H, promotes growth of hypophysectomized rats, assayed by observation of increased thickness of epiphyseal cartilage of the tibia and by observation of tail growth. Doses of homocysteic acid as low as 1 microgram per day for 4 days in the tibia assay and 2.5 milligrams per kilogram per day for 5 weeks in the tail assay were effective in promoting growth. Serum somatomedin activity, determined by the porcine cartilage disk assay, was also increased by homocysteic acid. These findings relate an area of sulfur amino acid metabolism to the physiological action of growth hormone, accelerated growth in homocystinuria, initiation of arteriosclerosis, and control of cellular growth.

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Homocysteic acid: an examination of its possible growth hormone-like activity. [Metabolism. 1979]
Homocysteic acid: an examination of its possible growth hormone-like activity.
Chrzanowska BL, Nitzan M, Phillips LS, Schulman JD. Metabolism. 1979 Jan; 28(1):80-4.
Evidence suggesting that the direct growth-promoting effect of growth hormone on cartilage in vivo is mediated by local production of somatomedin. [Proc Natl Acad Sci U S A. 1986]
Evidence suggesting that the direct growth-promoting effect of growth hormone on cartilage in vivo is mediated by local production of somatomedin.
Schlechter NL, Russell SM, Spencer EM, Nicoll CS. Proc Natl Acad Sci U S A. 1986 Oct; 83(20):7932-4.
Recombinant human insulin-like growth factor: testing the somatomedin hypothesis in hypophysectomized rats. [J Endocrinol. 1987]
Recombinant human insulin-like growth factor: testing the somatomedin hypothesis in hypophysectomized rats.
Skottner A, Clark RG, Robinson IC, Fryklund L. J Endocrinol. 1987 Jan; 112(1):123-32.
Review Growth hormone axis overview--somatomedin hypothesis. [Pediatr Nephrol. 2000]
Review Growth hormone axis overview--somatomedin hypothesis.
Daughaday WH. Pediatr Nephrol. 2000 Jul; 14(7):537-40.
Review Growth hormone and somatomedin. [Adv Metab Disord. 1974]
Review Growth hormone and somatomedin.
Hall K, Luft R. Adv Metab Disord. 1974; 7(0):1-36.

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Cited by 1 PubMed Central article

Chemical and biomechanical characterization of hyperhomocysteinemic bone disease in an animal model. [BMC Musculoskelet Disord. 2003]
Chemical and biomechanical characterization of hyperhomocysteinemic bone disease in an animal model.
Massé PG, Boskey AL, Ziv I, Hauschka P, Donovan SM, Howell DS, Cole DE. BMC Musculoskelet Disord. 2003 Feb 20; 4:2. Epub 2003 Feb 20.

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