Synthesis of potent and selective inhibitors against the proliferation of human coronary artery smooth muscle cells

Haruhisa Ogita; Yoshiaki Isobe; Haruo Takaku; Rena Sekine; Yuso Goto; Satoru Misawa; Hideya Hayashi

doi:10.1248/cpb.51.117

Synthesis of potent and selective inhibitors against the proliferation of human coronary artery smooth muscle cells

Chem Pharm Bull (Tokyo). 2003 Feb;51(2):117-21. doi: 10.1248/cpb.51.117.

Authors

Haruhisa Ogita¹, Yoshiaki Isobe, Haruo Takaku, Rena Sekine, Yuso Goto, Satoru Misawa, Hideya Hayashi

Affiliation

¹ Pharmaceuticals & Biotechnology Laboratory, Japan Energy Corporation, Saitama, Japan.

PMID: 12576643
DOI: 10.1248/cpb.51.117

Abstract

A series of diarylamide urea derivatives were synthesized and evaluated for their inhibitory activities against human coronary artery smooth muscle cells (SMCs) and human coronary artery endothelial cells (ECs). Compound 2h was much superior to Tranilast, in terms of both the potency of its inhibitory activity toward the proliferation of SMCs and the cell selectivity.

MeSH terms

Cell Division / drug effects
Cell Division / physiology
Cells, Cultured
Coronary Vessels / cytology*
Coronary Vessels / drug effects*
Coronary Vessels / metabolism
Growth Inhibitors / chemical synthesis*
Growth Inhibitors / pharmacology*
Humans
Myocytes, Smooth Muscle / cytology*
Myocytes, Smooth Muscle / drug effects*
Myocytes, Smooth Muscle / metabolism

Substances

Growth Inhibitors