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1: Chest. 2003 Feb;123(2):413-7.Click here to read Links
Comment in:
Chest. 2004 Jan;125(1):354.

Recovery of cell wall-deficient organisms from blood does not distinguish between patients with sarcoidosis and control subjects.

Brown ST, Brett I, Almenoff PL, Lesser M, Terrin M, Teirstein AS; ACCESS Research Group.

Department of Internal Medicine, The Mount Sinai Medical Center, and Bronx Veterans Affairs Medical Center, NY 10468, USA. sheldon.brown@med.va.gov

STUDY OBJECTIVE: To determine if cell wall-deficient forms (CWDF) of mycobacteria can be grown in culture of blood from subjects with sarcoidosis. DESIGN: A special multicenter study of sarcoidosis (A Case Control Etiologic Study of Sarcoidosis), supported by the National Heart, Lung, and Blood Institute. Patients and control subjects: Patients and control subjects were recruited at 10 institutions in the United States. Control subjects (controls) were of the same gender and race, and within 5 years of age as matching patients with sarcoidosis (cases). RESULTS: Cultures were incubated from 347 blood specimens (197 cases, 150 controls). Two investigators trained to recognize CWDF mycobacteria examined material obtained from culture tubes after 3 weeks. Structures thought to be CWDF were seen with equal frequency in cases (38%) and controls (41%). Thirty-nine percent of cases and 37% of controls were read as negative for CWDF. CONCLUSION: This study fails to confirm earlier reports that CWDF mycobacteria can be grown from the blood of patients with sarcoidosis, but not from control subjects.

PMID: 12576359 [PubMed - indexed for MEDLINE]