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Development. 2003 Mar;130(6):1059-68.

The parapineal mediates left-right asymmetry in the zebrafish diencephalon.

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  • 1Carnegie Institution of Washington, Department of Embryology, 115 W University Parkway, Baltimore, MD 21210, USA.

Abstract

The dorsal diencephalon (or epithalamus) of larval zebrafish displays distinct left-right asymmetries. The pineal complex consists of the pineal organ anlage and an unpaired, left-sided accessory organ - the parapineal. The neighboring brain nuclei, the left and right dorsal habenulae, show consistent differences in their size, density of neuropil and gene expression. Mutational analyses demonstrate a correlation between the left-right position of the parapineal and the laterality of the habenular nuclei. We show that selective ablation of the parapineal organ results in the loss of habenular asymmetry. The left-sided parapineal therefore influences the left-right identity of adjacent brain nuclei, indicating that laterality of the dorsal diencephalon arises in a step-wise fashion.

PMID:
12571098
[PubMed - indexed for MEDLINE]
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