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Nat Genet. 2003 Mar;33(3):342-4. Epub 2003 Feb 3.

Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL.

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  • 1Department of Internal Medicine I, Division of Hematology, University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria.

Abstract

After V(D)J-mediated translocations, signal joints are retained on one of the derivative chromosomes. We report here that such signal joints are highly reactive and constitute unstable genomic elements with potential oncogenic properties.

PMID:
12567187
[PubMed - indexed for MEDLINE]
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