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Bioorg Med Chem Lett. 2003 Feb 10;13(3):413-7.

2,3-Diarylbenzopyran derivatives as a novel class of selective cyclooxygenase-2 inhibitors.

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  • 1Drug Discovery, AmorePacific Corporation R&D Center, 314-1 Bora-ri, Kiheung-eup, Yongin-si, Kyounggi-do 449-729, South Korea. yhjoo@pacific.co.kr


A new series of cyclooxygenase-2(COX-2) inhibitors with naturally occurring flavone as the main skeleton has been synthesized and their biological activities were evaluated for cyclooxygenase inhibitory activity. Rational structural modifications were applied to potent COX-2 inhibitors to obtain the desired pharmacokinetic profiles for improved oral anti-inflammatory activity.

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