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Eur Arch Psychiatry Clin Neurosci. 2002 Dec;252(6):294-8.

Weight gain and glucose and lipid metabolism disturbances during antipsychotic medication: a review.

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  • 1Department of Psychiatry, University of Oulu, Oulu, Finland.


Antipsychotic medication is the mainstay of treatment for functional psychotic illnesses. However, for some patients weight gain and the disturbances in blood-lipid levels and glucose balance associated with their use are significant disadvantages, and pose health risks that may affect prognosis. A substantial body of evidence suggests that weight gain is at least partly related to the blocking effects of antipsychotic medication on serotonin- and histamine-mediated neurotransmission. The disadvantages associated with weight gain can be reduced by an appropriate choice of antipsychotic and avoidance of polypharmacy, by regular monitoring of the patient's weight, and, if necessary, by the patient's participation in a dieting programme.

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