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Nat Rev Mol Cell Biol. 2003 Feb;4(2):140-56.

Transglutaminases: crosslinking enzymes with pleiotropic functions.

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  • 1Department of Cell and Molecular Biology, Northwestern University, Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, Illinois 60611, USA. l-lorand@northwestern.edu

Abstract

Blood coagulation, skin-barrier formation, hardening of the fertilization envelope, extracellular-matrix assembly and other important biological processes are dependent on the rapid generation of covalent crosslinks between proteins. These reactions--which are catalysed by transglutaminases--endow the resulting supramolecular structure with extra rigidity and resistance against proteolytic degradation. Some transglutaminases function as molecular switches in cytoskeletal scaffolding and modulate protein-protein interactions. Having knowledge of these enzymes is essential for understanding the aetiologies of diverse hereditary diseases of the blood and skin, and various autoimmune, inflammatory and degenerative conditions.

PMID:
12563291
[PubMed - indexed for MEDLINE]
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