Nat Immunol. 2003 Mar;4(3):225-34. Epub 2003 Feb 3.

Lineage relationship and protective immunity of memory CD8 T cell subsets.

Wherry EJ, Teichgräber V, Becker TC, Masopust D, Kaech SM, Antia R, von Andrian UH, Ahmed R.

Source

Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.

Abstract

Memory CD8 T cells can be divided into two subsets, central (T(CM)) and effector (T(EM)), but their lineage relationships and their ability to persist and confer protective immunity are not well understood. Our results show that T(CM) have a greater capacity than T(EM) to persist in vivo and are more efficient in mediating protective immunity because of their increased proliferative potential. We also demonstrate that, following antigen clearance, T(EM) convert to T(CM) and that the duration of this differentiation is programmed within the first week after immunization. We propose that T(CM) and T(EM) do not necessarily represent distinct subsets, but are part of a continuum in a linear naive --> effector --> T(EM) --> T(CM) differentiation pathway.

Comment in

Nat Immunol. 2003 Mar;4(3):212-3.

PMID:: 12563257; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Grant Support

Publication Types

MeSH Terms

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Related citations

Unidirectional development of CD8+ central memory T cells into protective Listeria-specific effector memory T cells. [Eur J Immunol. 2006]
Unidirectional development of CD8+ central memory T cells into protective Listeria-specific effector memory T cells.
Huster KM, Koffler M, Stemberger C, Schiemann M, Wagner H, Busch DH. Eur J Immunol. 2006 Jun; 36(6):1453-64.
Strength of stimulus and clonal competition impact the rate of memory CD8 T cell differentiation. [J Immunol. 2007]
Strength of stimulus and clonal competition impact the rate of memory CD8 T cell differentiation.
Sarkar S, Teichgräber V, Kalia V, Polley A, Masopust D, Harrington LE, Ahmed R, Wherry EJ. J Immunol. 2007 Nov 15; 179(10):6704-14.
Simultaneous assessment of antigen-stimulated cytokine production and memory subset composition of memory CD8 T cells. [J Immunol Methods. 2006]
Simultaneous assessment of antigen-stimulated cytokine production and memory subset composition of memory CD8 T cells.
Jabbari A, Harty JT. J Immunol Methods. 2006 Jun 30; 313(1-2):161-8. Epub 2006 May 26.
Review CD8 T cell dysfunction during chronic viral infection. [Curr Opin Immunol. 2007]
Review CD8 T cell dysfunction during chronic viral infection.
Shin H, Wherry EJ. Curr Opin Immunol. 2007 Aug; 19(4):408-15. Epub 2007 Jul 25.
Review T memory cells: quality not quantity. [Curr Biol. 2002]
Review T memory cells: quality not quantity.
Sprent J. Curr Biol. 2002 Mar 5; 12(5):R174-6.

See reviews... See all...

Cited by over 100 PubMed Central articles

Safety and Immunogenicity of an HIV-1 Gag DNA Vaccine with or without IL-12 and/or IL-15 Plasmid Cytokine Adjuvant in Healthy, HIV-1 Uninfected Adults. [PLoS One. 2012]
Safety and Immunogenicity of an HIV-1 Gag DNA Vaccine with or without IL-12 and/or IL-15 Plasmid Cytokine Adjuvant in Healthy, HIV-1 Uninfected Adults.
Kalams SA, Parker S, Jin X, Elizaga M, Metch B, Wang M, Hural J, Lubeck M, Eldridge J, Cardinali M, et al. PLoS One. 2012; 7(1):e29231. Epub 2012 Jan 5.
From tumor immunosuppression to eradication: targeting homing and activity of immune effector cells to tumors. [Clin Dev Immunol. 2011]
From tumor immunosuppression to eradication: targeting homing and activity of immune effector cells to tumors.
Draghiciu O, Nijman HW, Daemen T. Clin Dev Immunol. 2011; 2011:439053. Epub 2011 Dec 8.
Non-hematopoietic cells in lymph nodes drive memory CD8 T cell inflation during murine cytomegalovirus infection. [PLoS Pathog. 2011]
Non-hematopoietic cells in lymph nodes drive memory CD8 T cell inflation during murine cytomegalovirus infection.
Torti N, Walton SM, Brocker T, Rülicke T, Oxenius A. PLoS Pathog. 2011 Oct; 7(10):e1002313. Epub 2011 Oct 27.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Lineage relationship and protective immunity of memory CD8 T cell subsets.
Lineage relationship and protective immunity of memory CD8 T cell subsets.
Nat Immunol. 2003 Mar ;4(3):225-34. Epub 2003 Feb 3 .

PubMed
Antioxidant activities of Physalis peruviana.
Antioxidant activities of Physalis peruviana.
Biol Pharm Bull. 2005 Jun ;28(6):963-6.

PubMed
Predicting individual survival after potentially curative esophagectomy for aden...
Predicting individual survival after potentially curative esophagectomy for adenocarcinoma of the esophagus or gastroesophageal junction.
Ann Surg. 2008 Dec ;248(6):1006-13.

PubMed
Parkinsonism and akathisia with quetiapine: three case reports.
Parkinsonism and akathisia with quetiapine: three case reports.
J Clin Psychiatry. 2008 Jul ;69(7):1189-91.

PubMed
Amyloid deposition of the breast.
Amyloid deposition of the breast.
AJR Am J Roentgenol. 2000 Dec ;175(6):1590.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: