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Am J Psychiatry. 2003 Feb;160(2):371-3.

Reduction of nightmares and other PTSD symptoms in combat veterans by prazosin: a placebo-controlled study.

Author information

  • 1Northwest Network VISN 20 Mental Illness Research, Eduation, and Clinical Center, VA Puget Sound Healthcare System, Seattle, USA. murray.raskind@med.va.gov

Abstract

OBJECTIVE:

Prazosin is a centrally active alpha(1) adrenergic antagonist. The authors' goal was to evaluate prazosin efficacy for nightmares, sleep disturbance, and overall posttraumatic stress disorder (PTSD) in combat veterans.

METHOD:

Ten Vietnam combat veterans with chronic PTSD and severe trauma-related nightmares each received prazosin and placebo in a 20-week double-blind crossover protocol.

RESULTS:

Prazosin (mean dose=9.5 mg/day at bedtime, SD=0.5) was superior to placebo for the three primary outcome measures: scores on the 1) recurrent distressing dreams item and the 2) difficulty falling/staying asleep item of the Clinician-Administered PTSD Scale and 3) change in overall PTSD severity and functional status according to the Clinical Global Impression of change. Total score and symptom cluster scores for reexperiencing, avoidance/numbing, and hyperarousal on the Clinician-Administered PTSD Scale also were significantly more improved in the prazosin condition, and prazosin was well tolerated.

CONCLUSIONS:

These data support the efficacy of prazosin for nightmares, sleep disturbance, and other PTSD symptoms.

PMID:
12562588
[PubMed - indexed for MEDLINE]
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