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    Wei Sheng Yan Jiu. 2001 Nov;30(6):333-5.

    [Inhibition the growth of human leukemia cells by Lycium barbarum polysaccharide].

    [Article in Chinese]
    Gan L, Wang J, Zhang S.

    Source

    School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.

    Abstract

    The effect and the mechanism of Lycium barbarum polysaccharide (LBP-X) on inhibiting the growth of human leukemia HL-60 cells were examined. LBP-X(20, 100, 500, 1000 mg/L) could inhibit the growth of HL-60 cells in dose-dependent manner and decrease the membrane fluidity of the cell. Agarose gel electrophoresis of DNA from the cells treated with LBP-X revealed a "DNA ladder" and positive TUNEL test. The results showed that the apoptosis of HL-60 cells induced by LBP-X maybe its important mechanism on anti-tumorgenesis.

    PMID:
    12561612
    [PubMed - indexed for MEDLINE]

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