Send to:

Choose Destination
See comment in PubMed Commons below
Zoolog Sci. 2003 Jan;20(1):43-7.

No effects of estrogen receptor overexpression on gonadal sex differentiation and reversal in medaka fish.

Author information

  • 1Center for Gene Science, Hiroshima University, Kagamiyama 1-4-2, Higashi-hiroshima 739-8527, Japan.


In order to elucidate a possible role of estrogen receptor in the gonadal sex differentiation and the sex reversal with sex steroids, we examined for the formation of testis or ovary in transgenic medaka fish overexpressing the medaka estrogen receptor under the constitutive medaka beta-actin promoter. The transgenic fish underwent the genetically determined gonadal differentiation and showed the same sex-reversal rates as those of wild-type non-transgenic fish after treatments with estrogen and androgen. These results present invaluable data to reconsider the role of estrogen receptor in the gonadal sex determination.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for BioOne
    Loading ...
    Write to the Help Desk