J Neurochem. 2003 Feb;84(3):618-20.

In situ imaging of specific binding of [3H]isatin in rat brain.

Crumeyrolle-Arias M, Medvedev A, Cardona A, Barritault D, Glover V.

Source

Laboratoire CRRET -CNRS FRE2412, Université Paris 12, Créteil, France. crumeyrolle@univ-paris12.fr

Abstract

Isatin is an endogenous indole that influences a range of processes both in vivo and in vitro. It has a distinct and discontinuous distribution in the brain, as well as in other mammalian tissues and body fluids. However, the distribution of isatin binding sites in the brain is not known. Using a real-time beta-imager we have investigated the distribution of [3H]isatin-specific binding in rat brain sections. The highest labeling was found in hypothalamic nuclei and in the cortex, hippocampus, and cerebellum. Administration of the mechanism based monoamine oxidase inhibitor, pargyline, reduced but did not abolish the specific binding of [3H]isatin in the rat brain. The distribution became cortex, cerebellum, hypothalamus > hippocampus > brain stem > thalamus approximately striatum.

PMID:: 12558982; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

TRITIUM - HSDB

Supplemental Content

Save items

Related citations in PubMed

Endogenous oxidized indoles share inhibitory potency against [3H]isatin binding in rat brain. [J Neural Transm Suppl. 2007]
Endogenous oxidized indoles share inhibitory potency against [3H]isatin binding in rat brain.
Crumeyrolle-Arias M, Medvedev A, Cardona A, Tournaire MC, Glover V. J Neural Transm Suppl. 2007; (72):29-34.
Isatin binding proteins in rat brain: in situ imaging, quantitative characterization of specific [3H]isatin binding, and proteomic profiling. [J Neurosci Res. 2009]
Isatin binding proteins in rat brain: in situ imaging, quantitative characterization of specific [3H]isatin binding, and proteomic profiling.
Crumeyrolle-Arias M, Buneeva O, Zgoda V, Kopylov A, Cardona A, Tournaire MC, Pozdnev V, Glover V, Medvedev A. J Neurosci Res. 2009 Sep; 87(12):2763-72.
Natriuretic peptide interaction with [3H]isatin binding sites in rat brain. [Brain Res. 2005]
Natriuretic peptide interaction with [3H]isatin binding sites in rat brain.
Medvedev A, Crumeyrolle-Arias M, Cardona A, Sandler M, Glover V. Brain Res. 2005 May 3; 1042(2):119-24.
Review [Isatin: possible role in functional interaction of natriuretic peptides and monoamines]. [Vopr Med Khim. 1997]
Review [Isatin: possible role in functional interaction of natriuretic peptides and monoamines].
Glover V, Medvedev AE, Sandler M. Vopr Med Khim. 1997 Nov-Dec; 43(6):515-21.
Review Function of endogenous monoamine oxidase inhibitors (tribulin). [J Neural Transm Suppl. 1998]
Review Function of endogenous monoamine oxidase inhibitors (tribulin).
Glover V. J Neural Transm Suppl. 1998; 52:307-13.

See reviews... See all...

Cited by 1 PubMed Central article

Biological targets for isatin and its analogues: Implications for therapy. [Biologics. 2007]
Biological targets for isatin and its analogues: Implications for therapy.
Medvedev A, Buneeva O, Glover V. Biologics. 2007 Jun; 1(2):151-62.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

In situ imaging of specific binding of [3H]isatin in rat brain.
In situ imaging of specific binding of [3H]isatin in rat brain.
J Neurochem. 2003 Feb ;84(3):618-20.

PubMed
Ergotamine and dihydroergotamine: history, pharmacology, and efficacy.
Ergotamine and dihydroergotamine: history, pharmacology, and efficacy.
Headache. 2003 Feb ;43(2):144-66.

PubMed
Waiting for scheduled services in Canada: development of priority-setting scorin...
Waiting for scheduled services in Canada: development of priority-setting scoring systems.
J Eval Clin Pract. 2003 Feb ;9(1):23-31.

PubMed
Giant condyloma of Buschke-Loewenstein in association with erythroderma.
Giant condyloma of Buschke-Loewenstein in association with erythroderma.
Clin Exp Dermatol. 2003 Jan ;28(1):46-9.

PubMed
[Pathogenesis of osteoporosis in rheumatoid arthritis].
[Pathogenesis of osteoporosis in rheumatoid arthritis].
Acta Med Austriaca. 2003 ;30(1):1-5.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

In situ imaging of specific binding of [3H]isatin in rat brain.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 1 PubMed Central article

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information