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Br J Surg. 2003 Feb;90(2):133-46.

Growth factors in the treatment of diabetic foot ulcers.

Author information

  • 1Unit of Cell and Molecular Biology, The Dental School, University of Dundee, Dundee, UK. s.p.bennett@doctors.org.uk

Abstract

BACKGROUND:

Chronic foot ulceration is a major source of morbidity in diabetic patients. Despite traditional comprehensive wound management, including vascular reconstruction, there remains a cohort of patients with non-responding wounds, often resulting in amputation. These wounds may benefit from molecular manipulation of growth factors to enhance the microcirculation.

METHODS:

A review of the current literature was performed using Pubmed, with secondary references obtained from key articles.

RESULTS AND CONCLUSION:

There has been a generally disappointing clinical outcome from growth factor trials, although topical platelet-derived growth factor has shown significant benefit and should be considered in non-healing, well perfused ulcers after failure of conventional wound care. The modulatory role of the extracellular matrix in the cellular response to growth factors and data from regenerative-type fetal wound healing are further areas of interest. The chemical induction of microvessel formation may become a future therapeutic option.

PMID:
12555288
[PubMed - indexed for MEDLINE]
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