Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Card Fail. 2002 Dec;8(6 Suppl):S512-7.

Apoptosis in heart failure represents programmed cell survival, not death, of cardiomyocytes and likelihood of reverse remodeling.

Author information

  • 1Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.

Abstract

Apoptosis is a highly orchestrated form of programmed cell death, and this is believed to contribute to continuous decline of ventricular function in heart failure. However, the apoptotic cascade is not completed in failing myocardium and DNA damage is prevented due to abolition of DNA fragmentation factors. The extranuclear apoptotic program is interrupted secondary to inhibition of activated caspase-3 by upregulated inhibitors of apoptotic process. During the apoptotic process, upstream step comprising extensive mitochondrial loss of cytochrome c may contribute to systolic dysfunction of heart. Intactness of nuclear blueprint underscores the likelihood of reverse remodeling that has been demonstrated in the post-LVAD myocardial specimens.

PMID:
12555167
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk